More Vitamin D Benefits...
A recent meta-analysis of twelve double blind, randomized controlled trials indicates that vitamin D3 promotes bone strength. The study involved almost 20,000 people supplementing with 400 to 800 i.u. cholecalciferol, vitamin D3. Results indicate that 700-800 i.u. cholecalciferol promoted hip and nonvertebral bone health, however 400 i.u. did not have the same effect. In another 3-year randomized controlled study, cholecalciferol and calcium supplementation lessened the risk of falling in women aged 65 or older.*
A recent trial selected a cross-sectional group of 80 elderly individuals from a longitudinal study researching cognitive function. The trial indicated that higher serum 25-hydroxyvitamin D levels were associated with positive mood and cognitive performance.*
A prospective, nested case-control study involving more than 7 million U.S. military personnel indicates that vitamin D may promote nerve health. The study reveals that high circulating levels of 25-hydroxyvitamin D were associated with nerve and myelin health. Another cohort study involving women from the Nurses' Health Study and Nurses' Health Study II indicates that supplemental vitamin D greater or equal to 400 i.u. per day promotes nerve health.*
Cellular Health of the Colon, Breast and Prostate
A review of 63 observational studies reveals the importance of healthy vitamin D serum levels for supporting normal cellular health of the prostate, colon and breast. A recent cohort study involving 1,095 men indicates that higher serum levels of vitamin D are associated with cellular health, particularly for the gastrointestinal tract. Additionally, a meta-analysis involving 5 trials suggests that a daily intake of 1,000-2,000 i.u. per day of vitamin D3 promotes colon cell health. A case-control study from within the Nurses Health Study indicates that healthy 25-hydroxyvitamin D plasma levels are associated with breast cell health. Furthermore, healthy plasma levels of 1,25 dihydroxyvitamin D, the most active vitamin D metabolite, may also be associated with healthy breast cell function.*
1. Bischoff-Ferrari HA, Willett WC, Wong JB, et al Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005 May 11 293(18):2257-64
2. Bischoff-Ferrari HA, Orav EJ, Dawson-Hughes B. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch Intern Med. 2006 Feb 27 166(4):424-30.
3. Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry. 2006 Dec 14(12):1032-40.
4. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006 Dec 20 296(23):2832-8.
5. Munger KL, Zhang SM, O'Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology. 2004 Jan 13 62(1):60-5.
6. Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. Am J Public Health. 2006 Feb 96(2):252-61.
7. Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willett WC. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst. 2006 Apr 5 98(7):451-9.
8. Gorham ED, Garland CF, Garland FC, et al. Optimal vitamin d status for colorectal cancer prevention a quantitative meta analysis. Am J Prev Med. 2007 Mar 32(3):210-6.
9. Bertone-Johnson ER, Chen WY, Holick MF, et al. Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2005 Aug 14(8):1991-7.
10. Pendas-Franco N, Gonzalez-Sancho JM, Suarez Y, et al. Vitamin D regulates the phenotype of human breast cancer cells. Differentiation. 2006 Dec.
For educational purposes only. Consult your physician for any health problems.
*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.